Document Detail

A role of the histaminergic system for the control of feeding by orexigenic peptides.
MedLine Citation:
PMID:  16872646     Owner:  NLM     Status:  MEDLINE    
A considerable number of neuropeptides are involved in the hypothalamic regulation of feeding behavior. We previously reported that leptin, the ob gene product, expressed its anorectic effect though the histaminergic system via histamine H(1) receptors. However, the interactions among the orexigenic neuropeptides, such as orexin-A, neuropeptide Y (NPY), and ghrelin, and the histaminergic system have not yet been clarified. In this study, we investigated the effect of the neuropeptides on the hypothalamic histamine release in rats, and on food intake and locomotor activity in H(1)-receptor knockout (H1R-KO) mice. Orexin-A increased the histamine release and locomotor activity, but not food intake, suggesting that the histaminergic system participates in arousal rather than feeding by orexin-A. NPY also increased histamine release, but its effect was not immediate. NPY-injected H1R-KO mice consumed more food than the wild-type mice; thus, the histaminergic system may act as a feedback factor downstream of NPY. Ghrelin did not affect histamine release, and it increased food intake, even in H1R-KO mice. Thus, ghrelin expresses its action in a histamine-independent manner.
Tomoko Ishizuka; Sachiko Nomura; Hiroshi Hosoda; Kenji Kangawa; Takeshi Watanabe; Atsushi Yamatodani
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-07-26
Journal Detail:
Title:  Physiology & behavior     Volume:  89     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Department of Medical Physics and Engineering, Graduate School of Allied Health Sciences, Faculty of Medicine, Osaka University, 1-7 Yamadaoka, Suita, 565-0871 Osaka, Japan.
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MeSH Terms
Analysis of Variance
Behavior, Animal
Eating / drug effects
Feeding Behavior / drug effects*
Histamine / metabolism*
Hypothalamus / drug effects,  metabolism
Intracellular Signaling Peptides and Proteins / pharmacology*
Mice, Knockout
Motor Activity / drug effects
Neuropeptide Y / pharmacology*
Neuropeptides / pharmacology*
Peptide Hormones / pharmacology*
Rats, Wistar
Receptors, Histamine H1 / deficiency
Time Factors
Reg. No./Substance:
0/Ghrelin; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptide Y; 0/Neuropeptides; 0/Peptide Hormones; 0/Receptors, Histamine H1; 0/orexins; 51-45-6/Histamine

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