Document Detail


The role of histamine release in shock.
MedLine Citation:
PMID:  1708189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More than 80 years after its discovery and nearly 70 years after its first being implicated in the mechanism of shock, the precise role of histamine (H) in the pathophysiology of the condition remains to be determined. The prevailing view over the decades has been that H is a noxious mediator contributing to the fatal outcome of shock. An adequate assessment of its role has long been hampered by the lack of a sufficiently sensitive and specific method for the measurement of H and by deficiencies of design in many studies. We now know that H is released in all types of shock. In low-output, high-resistance states, as in hypovolemic and cardiogenic shock, its effect (contrary to previous notions) appears to be beneficial, probably through the inhibition of excessive vasoconstriction and through a positive inotropic effect. In endotoxin shock the results are conflicting, but seem to indicate that H is not a lethal factor. In human septic shock, patients who died had higher H levels. The role of H release in the various forms of shock, both experimental and human, clearly needs an adequate, critical reevaluation, in carefully designed and executed studies using satisfactory methodology.
Authors:
S Nagy
Related Documents :
23181649 - Assessment of a simulation training exercise to teach intrauterine tamponade for the tr...
15032999 - Where to q in pep.
2654029 - The role of esophageal leads in the detection of exercise-induced postero-basal ischemia.
12685139 - Prevalence of t wave alternans in healthy subjects.
1623759 - P wave height during incremental exercise in patients with chronic airway obstruction.
23445289 - Relationship between dynamin 1 mutation status and characteristics of recurrent episode...
6695339 - Basal and exercise tests on morbidly obese patients before and after gastric bypass.
23843929 - Exercise for older adult inpatients with acute myelogenous leukemia: a pilot study.
11895569 - A comparison of the illness beliefs of people with angina and their peers: a questionna...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  76     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-22     Completed Date:  1991-05-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  IM    
Affiliation:
Institute of Experimental Surgery, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Histamine Antagonists / therapeutic use
Histamine Release / physiology*
Humans
Shock / drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
0/Histamine Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of neutrophils on histamine release from mast cells
Next Document:  Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3H-imipr...