Document Detail

The role of high frequency oscillatory ventilation in very preterm infants.
MedLine Citation:
PMID:  12011563     Owner:  NLM     Status:  MEDLINE    
The role of high frequency oscillatory ventilation (HFOV) for the treatment of respiratory disease in preterm infants remains uncertain. Animal work demonstrates reduced lung injury with HFOV compared to conventional ventilation (CV), and previous human trials suggest that in preterm infants HFOV reduces the incidence of chronic lung disease (CLD). However, the trials themselves have several limitations. In an attempt to conclusively establish the role of HFOV for the prevention of CLD in very preterm infants we conducted a large, UK based, multicentre trial. Preliminary results of this study suggest there are no significant differences between the two modes of ventilation regarding mortality and incidence of CLD.
Sandra Calvert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biology of the neonate     Volume:  81 Suppl 1     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2002  
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Department Child Health, St. George's Hospital, London, UK.
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MeSH Terms
Chronic Disease
Clinical Trials as Topic
High-Frequency Ventilation* / adverse effects
Infant, Newborn
Infant, Premature*
Lung Diseases / prevention & control*
Multicenter Studies as Topic

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