Document Detail

The role of heat shock protein 90 in the regulation of tumor cell apoptosis.
MedLine Citation:
PMID:  22268041     Owner:  NLM     Status:  In-Data-Review    
Programmed death of Jurkat tumor cells was studied under conditions of culturing with 17-AAG selective inhibitor of heat shock protein with a molecular weight of 90 kDa and etoposide. Apoptosis realization was evaluated by fluorescent microscopy with FITC-labeled annexin V and propidium iodide. Activity of caspase-3 was evaluated spectrophotometrically. Inhibition of heat shock protein with a molecular weight of 90 kDa activated the apoptotic program in Jurkat tumor cells and etoposide-induced apoptosis. The heat shock protein with a molecular weight of 90 kDa acted as apoptosis inhibitor in tumor cells.
E V Kaigorodova; N V Ryazantseva; V V Novitskii; M V Belkina; A N Maroshkina
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  150     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  450-2     Citation Subset:  IM    
Department of Fundamentals of Clinical Medicine, Department of Pathophysiology, Research and Education Center of Molecular Medicine, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia.
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