Document Detail


The role of heat shock protein 90 in the regulation of tumor cell apoptosis.
MedLine Citation:
PMID:  22268041     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Programmed death of Jurkat tumor cells was studied under conditions of culturing with 17-AAG selective inhibitor of heat shock protein with a molecular weight of 90 kDa and etoposide. Apoptosis realization was evaluated by fluorescent microscopy with FITC-labeled annexin V and propidium iodide. Activity of caspase-3 was evaluated spectrophotometrically. Inhibition of heat shock protein with a molecular weight of 90 kDa activated the apoptotic program in Jurkat tumor cells and etoposide-induced apoptosis. The heat shock protein with a molecular weight of 90 kDa acted as apoptosis inhibitor in tumor cells.
Authors:
E V Kaigorodova; N V Ryazantseva; V V Novitskii; M V Belkina; A N Maroshkina
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  150     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  450-2     Citation Subset:  IM    
Affiliation:
Department of Fundamentals of Clinical Medicine, Department of Pathophysiology, Research and Education Center of Molecular Medicine, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk, Russia. zlobinae@mail.ru.
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