| The role of heart-type fatty acid-binding protein in predicting properties of coronary atherosclerosis in patients with acute coronary syndrome. | |
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MedLine Citation:
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PMID: 20679894 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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INTRODUCTION: Fatty acid-binding protein (FABP) is an independent predictor of cardiac events. However, the relation between increasing FABP and coronary atherosclerosis is unknown. We have investigated the relation between FABP and angiographic properties of coronary atherosclerosis in patients with acute coronary syndrome (ACS). METHODS: The study population consisted of 93 patients with ACS (mean age: 56±10 years). Patients presenting to the emergency department within 2 h after onset of anginal symptoms were enrolled in the study. FABP was measured at second, fourth and sixth hours of chest pain. Cut-off FABP was accepted as 1.9 ng/ml. Coronary atherosclerosis was assessed with diseased vessel number (≥50 and ≥70% luminal narrowing), Gensini and extent scores. RESULTS: Median FABP-2 was 2.9 ng/ml (interquartile range: 1.6-10.4). Peak FABP was measured at fourth hour [median: 35.0 ng/ml (interquartile range: 2-77)]. There was a nonsignificant relation between angiographic findings and FABP-2. At fourth hour, Gensini, extent score and diseased vessel number were significantly higher above the cut-off level of FABP-4 (Gensini score: 3.7±3.4 vs. 6.2±3.4, P=0.005; extent score: 11.1±10 vs. 22.3±19.2, P=0.007; diseased vessel: 0.7±0.6 vs. 1.6±1.0, P=0.003, respectively). The sensitivity of FABP-2 for at least 50% lesion was 70%. The highest sensitivity was obtained at fourth hour (85% for ≥50% and 88% for ≥70% lesions). The sensitivity and positive predictive values for revascularization were 70 and 77% for FABP-2, 89 and 80% for FABP-4 and 89 and 81% for FABP-6. CONCLUSION: FABP levels are closely related with angiographic properties of patients with ACS. FABP may be an early and important marker for predicting the coronary anatomy and decision of treatment. |
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Authors:
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Nihat Kalay; Mikail Yarlioglues; Idris Ardic; Mehmet Gungor Kaya; Alper Vardar; Tugrul Inanc; Ali Dogan; Ibrahim Ikizceli; Fatih Koç; Abdurrahman Oguzhan; Ali Ergin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Coronary artery disease Volume: 21 ISSN: 1473-5830 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 435-40 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Erciyes University, Kayseri, Turkey. nihatkalay@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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