Document Detail

The role of the gut mucosal immunity in the development of tolerance versus development of allergy to food.
MedLine Citation:
PMID:  20629265     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To provide an overview on the role of gut mucosal immunity in the development of tolerance to food versus allergy to food. RECENT FINDINGS: The gastrointestinal tract, through innate and specific immunologic factors, acts as a defense against ingested antigens. In addition to the mucous membrane integrity and the digestion, numerous specific immunologic cells and mediators orchestrate such defensive mechanisms. In case of food antigens, the outcome is usually in favor of tolerance. Defects in that barrier, however, can lead to the development of aberrant immunologic responses, including hypersensitivity reactions. SUMMARY: The prevailing evidence is that healthy mucosal immunity plus appropriate feeding regimen during early infancy are in favor of food tolerance. However, in addition to genetic predisposition, development of allergy is facilitated by defects in the gut barrier (immune or nonimmune) and the food allergen load.
Bassem G Chahine; Sami L Bahna
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Publication Detail:
Type:  Corrected and Republished Article; Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  10     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  394-9     Citation Subset:  IM    
Allergy & Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA.
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MeSH Terms
Antigens / immunology
Dietary Proteins / immunology
Food Hypersensitivity / etiology*,  immunology
Immune Tolerance*
Immunity, Mucosal*
Infant, Newborn
Intestinal Mucosa / immunology*
Reg. No./Substance:
0/Antigens; 0/Dietary Proteins
Corrected and Republished From:
Curr Opin Allergy Clin Immunol. 2010 Jun;10(3):220-5   [PMID:  20431370 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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