Document Detail

The role of gut hormones in the regulation of body weight and energy homeostasis.
MedLine Citation:
PMID:  19563862     Owner:  NLM     Status:  MEDLINE    
Obesity is one of the greatest public health challenges of the 21st century with 1.6 billion adults currently classified as being overweight and 400 million as obese. Obesity is causally associated with type 2 diabetes, hypertension, cardiovascular disease, obstructive sleep apnoea and certain forms of cancer and is now one of the leading causes of mortality and morbidity worldwide. The gastrointestinal tract is the largest endocrine organ in the body producing hormones that have important sensing and signaling roles in regulating body weight and energy expenditure. The last decade has witnessed a marked increase in our understanding of the role of gut hormones in energy homeostasis. Consequently, strategies aimed at modulating circulating gut hormone concentrations or targeting their receptors are being developed as potential pharmacotherapies for obesity. This review summarizes the current knowledge regarding the mechanisms, sites of action and effects of the anorectic gut hormones peptide tyrosine-tyrosine (PYY), pancreatic polypeptide (PP), oxyntomodulin, and amylin and of the unique orexigenic hormone, ghrelin.
Efthimia Karra; Rachel L Batterham
Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-27
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  316     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-05     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  120-8     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Amyloid / genetics,  metabolism
Body Weight / physiology*
Energy Metabolism / physiology*
Gastrointestinal Hormones / genetics,  metabolism*
Gastrointestinal Tract / anatomy & histology,  metabolism
Ghrelin / genetics,  metabolism
Homeostasis / physiology*
Islet Amyloid Polypeptide
Obesity / complications,  physiopathology,  surgery
Oxyntomodulin / genetics,  metabolism
Pancreatic Polypeptide / genetics,  metabolism
Peptide YY / genetics,  metabolism
Grant Support
G108/551//Medical Research Council
Reg. No./Substance:
0/Amyloid; 0/Gastrointestinal Hormones; 0/Ghrelin; 0/Islet Amyloid Polypeptide; 0/Oxyntomodulin; 106388-42-5/Peptide YY; 59763-91-6/Pancreatic Polypeptide

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