| The role of growth factors in cartilage metabolism. | |
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MedLine Citation:
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PMID: 8210575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The formation of articular cartilage defects in osteoarthritis arise due to an imbalance between biosynthetic and catabolic processes affecting the extracellular matrix. The compensatory synthesis of extracellular matrix proteins required to re-established normal cartilage homeostasis may be compromised by the failure of affected chondrocytes to respond to growth-stimulating peptides. Growth factors and cytokines may act synergistically to attenuate or boost chondrocyte responses. An understanding of how chondrocytes in osteoarthritic joints respond to growth factors could aid in the development of a rationale for designing new therapies to control the progression of osteoarthritic pathology. |
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Authors:
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C J Malemud |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Rheumatic diseases clinics of North America Volume: 19 ISSN: 0889-857X ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-11-15 Completed Date: 1993-11-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 569-80 Citation Subset: IM |
Affiliation:
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Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cartilage, Articular / metabolism* Fibroblast Growth Factors / physiology Growth Substances / physiology* Humans Receptors, Cell Surface / physiology Somatomedins / physiology Transforming Growth Factor beta / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG-02205/AG/NIA NIH HHS; AR-20618/AR/NIAMS NIH HHS; AR-37726/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 0/Receptors, Cell Surface; 0/Somatomedins; 0/Transforming Growth Factor beta; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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