Document Detail

A role for glutathione disulfide as a scavenger of oxygen radicals produced by 2,3-dichloro-1,4-naphthoquinone.
MedLine Citation:
PMID:  6318284     Owner:  NLM     Status:  MEDLINE    
The addition of 2,3-dichloro-1,4-naphthoquinone (CNQ) to isolated mitochondria supplemented with GSSG resulted in a respiratory burst with the production of O2- and H2O2, and a decrease in the level of measurable disulfide. Superoxide generated by the xanthine oxidase system or by CNQ-treated mitochondria caused the reduction of GSSG to GSH. Both disulfide reductions were partially sensitive to exogeneous SOD. GSSG was also shown to interfere with the epinephrine - adrenochrome superoxide assay system. The findings reported herein support the conclusion that GSSG is capable of scavenging O2- and has the potential to scavenge other free radicals by a similar mechanism.
C A Pritsos; R S Pardini
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  42     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  271-80     Citation Subset:  IM    
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MeSH Terms
Epinephrine / metabolism
Glutathione / analogs & derivatives*,  metabolism
Glutathione Disulfide
Mitochondria, Liver / metabolism
Naphthoquinones / metabolism*
Superoxides / metabolism*
Reg. No./Substance:
0/Naphthoquinones; 11062-77-4/Superoxides; 117-80-6/dichlone; 27025-41-8/Glutathione Disulfide; 51-43-4/Epinephrine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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