Document Detail


The role of glucagon like peptide-2 in controlling intestinal function in human infants: regulator or bystander?
MedLine Citation:
PMID:  22100593     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The regulation of nutrient absorptive capacity is a critical factor in the normal growth and development of infants of all species. In human infants this is a common problem following surgical resection; the process of adaptation, or up-regulation of nutrient transport capacity is the physiologic process, which allows patients to transition to enteral feeding. The specific mechanisms which control this are still relatively poorly understood but are likely relevant for most mammals with an ontogeny of intestinal function related to the weaning process. Many actions of the entero-endocrine hormone glucagon-like peptide (GLP)-2 indicate that it may be a key factor in regulating physiologic intestinal development, nutrient absorptive capacity and the process of adaptative upregulation of nutrient absorption following resection. This article will review the biology of GLP-2 which is preserved across a broad range of species. This will include the production of GLP-2 in the L cell, the regulation of GLP-2 release and the mechanism of action. The GLP-2 receptor is specifically located on enteric neurons, and pericryptal myofibroblast; thus, effects on the intestinal mucosa involve a second messenger. We will review the functioning of this system in the developing human infant and the role of GLP-2 in the regulation of adaptation, with the general implications for nutrient absorption in animals and humans.
Authors:
D L Sigalet
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-18
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, T3B 6A8.
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