| The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output. | |
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MedLine Citation:
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PMID: 18367504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuron-to-glia, glia-to-neuron, and glia-to-glia communication are implicated in the modulation of neuronal activity and synaptic transmission relevant to reproduction. Glial cells play an important role in neuroendocrine regulation and participate in the sexual differentiation of neuronal connectivity of brain regions involved in the control of reproductive neuroendocrine output. During puberty, modifications in the morphology and chemistry of astrocytes and tanycytes in the hypothalamus and median eminence influence the maturation of the neuronal circuits controlling the secretion of GnRH. During adult reproductive life, the glial cells participate in the transient remodeling of neuronal connectivity in the preoptic area, the arcuate nucleus, the median eminence, and other brain regions involved in the control of reproduction. Gonadal hormones regulate glial plasticity by direct and indirect effects and regulate various other endocrine signals, local soluble factors and adhesion molecules that also affect glial function and glia-to-neuron communication. The glial cells, therefore, are central to the coordination of endocrine and local inputs that bring about neural plasticity and adapt reproductive capacity to homeostatic signals. |
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Authors:
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Luis Miguel Garcia-Segura; Betty Lorenz; Lydia L DonCarlos |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 135 ISSN: 1741-7899 ISO Abbreviation: Reproduction Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 419-29 Citation Subset: IM |
Affiliation:
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Instituto Cajal, CSIC, Avenida Doctor Arce 37, E-28002 Madrid, Spain. lmgs@cajal.csic.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Communication Gonadotropin-Releasing Hormone / physiology* Humans Hypothalamus* Neuroglia / physiology* Neuronal Plasticity Neurons / physiology* Neurosecretory Systems / physiology* Reproduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH62588/MH/NIMH NIH HHS; MH69995/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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