Document Detail


The role of genetics and environment in the rise of childhood food allergy.
MedLine Citation:
PMID:  21771119     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Food allergy is a growing clinical and public health problem world-wide. The rising incidence is occurring more rapidly than changes to the genome sequence would allow, but it is yet to be determined whether environmental factors might act in interaction with genetic risk. That is to say, are environmental factors more likely to affect those genetically at risk? Family history is a strong risk factor for the development of food allergy as it co-aggregates with other atopic diseases and as such genetic factors do play an important role in food allergy risk. However, significant interest has now turned to the role of epigenetic modifications of the genome as the major mediator of gene-environment interaction. The consideration of the role of epigenetics in food allergy is likely to provide an insight into aetiological and biological disease mechanisms. This paper discusses the current state of knowledge regarding genetic and environmental risk factors for food allergy, and considers the potential for furthering our understanding of food allergy aetiology by examining the role of epigenetic variation.
Authors:
T H-T Tan; J A Ellis; R Saffery; K J Allen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-19
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  -     ISSN:  1365-2222     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Vic., Australia Department of Paediatrics, University of Melbourne, The Royal Children's Hospital, Parkville, Vic., Australia Department of Physiology, University of Melbourne, Melbourne, Vic., Australia Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Parkville, Vic., Australia Department of Allergy and Immunology, The Royal Children's. Hospital, Parkville, Vic., Australia.
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