Document Detail


The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.
MedLine Citation:
PMID:  23274701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroblastoma is a highly heterogeneous tumor accounting for 15 % of all pediatric cancer deaths. Clinical behavior ranges from the spontaneous regression of localized, asymptomatic tumors, as well as metastasized tumors in infants, to rapid progression and resistance to therapy. Genomic amplification of the MYCN oncogene has been used to predict outcome in neuroblastoma for over 30 years, however, recent methodological advances including miRNA and mRNA profiling, comparative genomic hybridization (array-CGH), and whole-genome sequencing have enabled the detailed analysis of the neuroblastoma genome, leading to the identification of new prognostic markers and better patient stratification. In this review, we will describe the main genetic factors responsible for these diverse clinical phenotypes in neuroblastoma, the chronology of their discovery, and the impact on patient prognosis.
Authors:
Raquel Domingo-Fernandez; Karen Watters; Olga Piskareva; Raymond L Stallings; Isabella Bray
Publication Detail:
Type:  Journal Article; Review     Date:  2012-12-29
Journal Detail:
Title:  Pediatric surgery international     Volume:  29     ISSN:  1437-9813     ISO Abbreviation:  Pediatr. Surg. Int.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-08-19     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8609169     Medline TA:  Pediatr Surg Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  101-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Chromosome Deletion
Chromosome Mapping / methods
Epigenomics / methods*
Humans
Neuroblastoma / genetics*
Grant Support
ID/Acronym/Agency:
R01 CA127496/CA/NCI NIH HHS
Comments/Corrections

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