| The role of gastroesophageal reflux in the pathogenesis of laryngeal carcinoma. | |
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MedLine Citation:
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PMID: 12430127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroesophageal reflux (GER) has been strongly associated with carcinogenesis of the lower esophagus and development of several otolaryngologic disorders. Epidemiologic studies support concept that the malignant transformation of laryngeal mucosal surfaces is due to GER-initiated chronic laryngeal inflammation. However, large clinical studies with matched control groups and further experimental investigations are necessary to ascertain the relationship between reflux and laryngeal carcinoma. This review stresses that early diagnosis of GER disease, based on clinical suspicion, ambulatory 24-hour double-probe pH monitoring, and endoscopic examination, as well as effective treatment of reflux, are considered the keys for relief of symptomatology and preventing the chronic irritation of the laryngeal mucosa that may contribute to the development of laryngeal carcinoma. |
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Authors:
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Dimitrios Assimakopoulos; George Patrikakos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of otolaryngology Volume: 23 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-11-13 Completed Date: 2003-03-27 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 351-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002, Elsevier Science (USA). All rights reserved.) |
Affiliation:
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Department of Otorhinolaryngology, University of Ioannina Medical School, Ioannina 45110, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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etiology* Gastroesophageal Reflux / complications*, pathology Humans Laryngeal Mucosa / pathology Laryngeal Neoplasms / etiology* Precancerous Conditions / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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