Document Detail

The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat.
MedLine Citation:
PMID:  491866     Owner:  NLM     Status:  MEDLINE    
In vivo studies were carried out in young Sprague-Dawley rats to examine the role of gastric lipolysis on fat absorption and bile acid metabolism. When fed by gastric perfusion 5 times (corn oil, 4 g/day) their usual dietary intake of fat, rats deprived of lingual lipase by the creation of an esophageal fistula had a significant degree of fat and bile acid malabsorption as well as a shortened bile acid half-life when compared to animals with a gastrostomy. The % fat absorption, bile acid loss and bile acid pool were normal in 2 groups of esophageal fistula rats fed the same quantity of corn oil or twice (8 g/day) that amount as a fine emulsion. In view of a negligible gastric lipase activity in animals with an esophageal fistula and of decreased hydrolysis of a triglyceride test meal, these data suggest that gastric lipolysis is of physiological importance in situations where lipolytic mechanisms are stressed by a large fat intkae. Its principal role is to potentiate intestinal lipolysis by facilitating the emulsification of dietary lipids through its formed products and, therefore, the contact of pancreatic lipase with its substrates.
C C Roy; M Roulet; D Lefebvre; L Chartrand; G Lepage; L A Fournier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  14     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1979-12-29     Completed Date:  1979-12-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  811-5     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / metabolism*
Dietary Fats*
Enterohepatic Circulation
Gastric Mucosa / metabolism*
Intestinal Absorption*
Lipase / metabolism
Lipid Metabolism
Lipid Mobilization*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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