| The role of garlic in hepatopulmonary syndrome: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 20352147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increased nitric oxide production in cirrhosis has been commonly implicated in the genesis of hepatopulmonary syndrome (HPS). Initial studies suggested that garlic, a constituent of the daily diet, may have a role in the treatment of HPS by altering nitric oxide production. OBJECTIVE: To evaluate the effects of oral garlic supplementation on arterial blood gas parameters, and overall morbidity and mortality in patients with HPS. METHODS: Twenty-one and 20 HPS patients were randomly assigned to receive either oral garlic supplementation or placebo, respectively, and were evaluated monthly over a period of nine to 18 months. RESULTS: After nine months, garlic supplementation was associated with a 24.66% increase in baseline arterial oxygen levels (83.05 mmHg versus 66.62 mmHg; P<0.001), compared with only a 7.37% increase (68.75 mmHg versus 64.05 mmHg; P=0.02) among subjects in the placebo group. There was also a 28.35% decrease in alveolar-arterial oxygen gradient (21.35 mmHg versus 29.77 mmHg; P<0.001) among patients with HPS who received garlic, in contrast with only a 10.73% decrease (29.11 mmHg versus 32.61 mmHg; P=0.12) among those in the placebo group. After nine months, the arterial oxygen level was significantly higher (83.05 mmHg versus 68.75 mmHg; P<0.001) and the alveolar-arterial oxygen gradient was significantly lower (21.35 mmHg versus 29.11 mmHg; P<0.001) among patients receiving garlic compared with those receiving placebo. Reversal of HPS was observed in 14 of 21 patients (66.67%) on garlic supplementation (intent-to-treat analysis) and in one of 20 patients (5%) on placebo. Two of 21 patients undergoing garlic supplementation died during follow-up in contrast to seven of 20 patients who were on placebo. CONCLUSIONS: Garlic supplementation may be beneficial in patients with HPS for the reversal of intrapulmonary shunts as well as reducing hypoxemia and mortality. |
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Authors:
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Binay K De; Deep Dutta; Subrata K Pal; Subhabrata Gangopadhyay; Sumanta Das Baksi; Adyapad Pani |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Canadian journal of gastroenterology = Journal canadien de gastroenterologie Volume: 24 ISSN: 0835-7900 ISO Abbreviation: Can. J. Gastroenterol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-05-04 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 8807867 Medline TA: Can J Gastroenterol Country: Canada |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Medical College Calcutta, India. binaykde@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anoxia / drug therapy, etiology Blood Gas Analysis Double-Blind Method Female Follow-Up Studies Garlic / chemistry* Hepatopulmonary Syndrome / drug therapy*, mortality, physiopathology Humans Male Middle Aged Oxygen / metabolism Phytotherapy / methods* Young Adult |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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