| The role of gamma-PET in the evaluation of patients with recurrent squamous cell cancer of the head and neck. | |
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MedLine Citation:
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PMID: 16053847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Squamous cell carcinoma (SCC) is the most common cancer of the head and neck (HNC). Advanced HNC warrants extensive ablative and reconstructive procedures, significantly altering locoregional anatomy, while radiation treatment further adds to the distortion. Anatomic imaging is therefore often inconclusive in suspected recurrent HNC. Functional imaging with fluorodeoxyglucose-positron emission tomography (FDG-PET) has been reported contributory in the evaluation of patients with SCC. While most reports are from dedicated PET systems, full ring PET is of limited availability and gamma-PET may offer a suitable compromise. The therapeutic impact of gamma-PET in patients with suspected recurrent HNC was retrospectively evaluated. Seventeen patients were evaluated. All had undergone surgery for HNC, 16 also received radiotherapy. gamma-PET scans were compared to anatomic imaging, histopathology and clinical follow-up. The impact of the FDG-PET scan on patient management was then evaluated. Eleven positive findings were confirmed. Two false positives were due to radiation changes, a recognized pitfall. There were no false negatives. Overall accuracy of the 18F-FDG gamma-PET scans was 88% with considerable effect on patient management. Gamma-PET with FDG appears valuable in the evaluation of suspected recurrent HNC, and may provide a suitable alternative when dedicated PET is unavailable. |
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Authors:
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E Goshen; R Yahalom; Y P Talmi; G Rotenberg; Y Oksman; S T Zwas |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: 34 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-01 Completed Date: 2005-08-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: Denmark |
Other Details:
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Languages: eng Pagination: 386-90 Citation Subset: D; IM |
Affiliation:
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Department of Nuclear Medicine, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv 52621, Israel. egoshen@sheba.health.gov.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use Gamma Cameras Head and Neck Neoplasms / radionuclide imaging* Humans Male Middle Aged Neoplasm Recurrence, Local / radionuclide imaging* Positron-Emission Tomography / instrumentation, methods* Radiopharmaceuticals / diagnostic use Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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