| The role of gallium-67-citrate in the detection of phenytoin-induced pneumonitis. | |
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MedLine Citation:
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PMID: 8113900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A patient with a history of cardiac transplant presented with a fever of undetermined etiology. The patient had been on multiple medications, including phenytoin, which can occasionally cause allergic or hypersensitivity pneumonitis. A chest x-ray and CT scan of the chest revealed no active disease. A 67Ga study was obtained after intravenous administration of 377.4 MBq (10.2 mCi) of 67Ga-citrate. The images showed diffuse intense lung uptake bilaterally. Bronchoscopic biopsy revealed hypersensitivity pneumonitis. Phenytoin was withdrawn and corticosteroid was started in therapeutic doses. A follow-up gallium study obtained 25 days after the baseline demonstrated marked improvement in the lungs with concurrent clinical recovery. This case illustrates the usefulness of 67Ga in the detection of drug-induced pneumonitis and in the follow-up of response to therapy. |
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Authors:
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A S Khan; S Dadparvar; S J Brown; W J Slizofski; R Roman; L Krishna; M Meihoffer |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 35 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-03-31 Completed Date: 1994-03-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 471-3 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102-1192. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolitis, Extrinsic Allergic
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chemically induced*,
radionuclide imaging Citrates / diagnostic use* Citric Acid Drug Hypersensitivity / radionuclide imaging* Gallium Radioisotopes / diagnostic use* Heart Transplantation Humans Lung / radionuclide imaging* Male Middle Aged Phenytoin / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Gallium Radioisotopes; 57-41-0/Phenytoin; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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