Document Detail


On the role of galectin-3 in cancer apoptosis.
MedLine Citation:
PMID:  15843888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Galectin-3, a member of the beta-galactoside-binding gene family, is a multifunctional protein implicated in a variety of biological functions, including tumor cell adhesion, proliferation, differentiation, angiogenesis, cancer progression and metastasis. Recent studies revealed that intracellular galectin-3 exhibits the activity to suppress drug induced apoptosis and anoikis (apoptosis induced by the loss of cell anchorage) that contribute to cell survival. Resistance to apoptosis is essential for cancer cell survival and plays a role in tumor progression. Conversely, it was recently shown that tumor cells' secreted galectin-3 induces T-cells' apoptosis, thus playing a role in the immune escape mechanism during tumor progression through induction of apoptosis of cancer-infiltrating T-cells. This review summarizes recent evidences on the role of galectin-3 as an anti-apoptotic and/or pro-apoptotic factor in various cell types and discusses the recent understanding of the molecular mechanisms of galectin-3 role in apoptosis. We also suggest potential directions for further analyses of this multifunctional protein.
Authors:
S Nakahara; N Oka; A Raz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  10     ISSN:  1360-8185     ISO Abbreviation:  Apoptosis     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-21     Completed Date:  2005-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Affiliation:
Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cell Differentiation
Cell Line
Cell Membrane / metabolism
Disease Progression
Galectin 3 / metabolism,  physiology*
Gene Expression Regulation
Humans
Jurkat Cells
Ligands
Mice
Models, Biological
Neoplasms / metabolism,  pathology*
Neovascularization, Pathologic
Phosphorylation
T-Lymphocytes / cytology,  metabolism
Grant Support
ID/Acronym/Agency:
CA46120/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Galectin 3; 0/Ligands

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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