Document Detail


The role of free fatty acids in the regulation of lipolysis by human adipose tissue cells.
MedLine Citation:
PMID:  214668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of added fatty acid on lipolysis and cyclic AMP concentration of human adipose tissue cells was studied. The addition of sodium oleate decreased the lipolytic response of adipocytes to 10(-7) M isoproterenol. Inhibition was detectable with the lowest quantity of oleate added, 0.2 mM, and was progressively greater with increasing quantities of added fatty acid. Palmitic and linoleic acids were as effective as oleic acid in suppressing isoproterenol-stimulated lipolysis. Suppression of cyclic AMP formation was detectable within one minute after the addition of oleate. Cyclic AMP formation, suppressed by accumulated fatty acids, could not be stimulated by the addition of fresh isoproterenol. However, after the accumulated fatty acids were removed by buffer change, cyclic AMP formation was stimulated by fresh isoproterenol. These findings are consistent with the view that fatty acids are physiologically significant regulators of lipolysis.
Authors:
T W Burns; P E Langley; B E Terry; G A Robinson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  27     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-02-12     Completed Date:  1979-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1755-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects,  metabolism*
Cyclic AMP / metabolism
Fatty Acids, Nonesterified / pharmacology*
Humans
Isoproterenol / pharmacology
Kinetics
Linoleic Acids / pharmacology
Lipid Mobilization / drug effects*
Oleic Acids / pharmacology
Palmitic Acids / pharmacology
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Linoleic Acids; 0/Oleic Acids; 0/Palmitic Acids; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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