Document Detail

The role of food allergy in atopic dermatitis.
MedLine Citation:
PMID:  20929606     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) affects ∼10% of children. Food allergy is a known provoking cause of AD in a subset of affected children. A literature search of PubMed and Medline was conducted to review the epidemiology and pathophysiology of AD, with special focus on the role of food allergy in the development of AD, its management, and its long-term preventive strategies. A literature search of PubMed and Medline was conducted. Food allergens readily provoke AD in ∼35% of patients, as proven through double-blind placebo-controlled food challenge studies. Milk, egg, wheat, soy, and peanut account for 75% of the cases of food-induced AD. However, the positive predictive values of the parental history, skin-prick tests, or serum tests for detecting food-specific IgE are low, making these unsuitable for use as single diagnostic modalities. Therefore, the use of a food challenge test is very helpful in objectively confirming the history or positive tests. Elimination diets are often helpful in challenge-proven cases, but care must be taken to evaluate the nutritional status of the child. There are few effective long-term strategies to prevent the development of food allergen-induced AD. Early onset of AD has been shown to be a risk factor for the development of other allergic diseases, including other food allergy/sensitization, as part of the atopic march. Treatment of other causes of AD, such as barrier dysfunction and cutaneous infection, are of equal importance to food allergen avoidance. Food allergy is an important provoking cause of AD, but it is only relevant in ∼35% of affected individuals.
Matthew Greenhawt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  31     ISSN:  1539-6304     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-02-07     Revised Date:  2011-08-12    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-7     Citation Subset:  IM    
University of Michigan Food Allergy Center, The University of Michigan Medical School, Ann Arbor, 48106, USA.
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MeSH Terms
Allergens / diagnostic use,  immunology
Arachis hypogaea / immunology
Child, Preschool
Dermatitis, Atopic / epidemiology,  etiology*,  physiopathology,  therapy
Food Hypersensitivity / complications*,  epidemiology,  etiology
Milk / immunology
Skin Tests
Triticum / immunology
Reg. No./Substance:

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