| The role of folate deficiency in electrophysiological neuropathy of experimental hepatoma of the rats. | |
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MedLine Citation:
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PMID: 6291303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental hepatoma of the rats was induced by chronic administration of 3'-methyl-dimethylamino-azobenzene. The folate level of the hepatoma-bearing rats tended to be low as compared with that of normal controls, and the co-existence of folate deficiency and reduced motor nerve conduction velocity of the dorsal nerve trunks appeared not uncommon. The hepatoma-bearing rats revealed the disturbance of serine to glycine conversion in serum, and folate administration to them prevented electrophysiological neuropathy along with normalization of serine to glycine conversion. Therefore, the reduced motor nerve conduction velocity could be at least in part the result of a metabolic impairment due to folate deficiency. |
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Authors:
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H Matsumoto; S Chiba; S Kikuchi; T Wada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 64 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-12-16 Completed Date: 1982-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 446-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Folic Acid Deficiency / complications* Glycine / blood Liver Neoplasms, Experimental / metabolism*, physiopathology Male Neural Conduction Peripheral Nervous System Diseases / etiology*, metabolism, physiopathology Rats Rats, Inbred Strains Serine / blood |
| Chemical | |
Reg. No./Substance:
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56-40-6/Glycine; 56-45-1/Serine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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