Document Detail

The role of fine-needle aspiration in the diagnosis of thyroid lymphoma: a retrospective study of nine cases and review of published series.
MedLine Citation:
PMID:  20154034     Owner:  NLM     Status:  MEDLINE    
AIMS: To review the clinicopathological, cytomorphological and immunophenotyping data from new cases and published series of thyroid lymphoma diagnosed by fine-needle aspiration (FNA), in order to identify useful diagnostic features. METHODS: Cases from 1988 to 2009 with an FNA diagnosis of thyroid lymphoma were selected from hospital records. An electronic MEDLINE and EMBASE search retrieved published series from 1980 to 2009. Available clinical, cytomorphological and immunophenotyping data from all cases were collected. In our cases, cytology slides and available surgical specimens were also reviewed. RESULTS: There were nine cases from eight of our patients, and 70 reviewed cases from eight series with at least four patients each. The most common presentation was a rapidly enlarging thyroid mass. Average patient age was 61 years in reviewed cases and 72 years in our cases. Large-cell lymphoma was the predominant subtype, revealing relatively monotonous populations of large, abnormal lymphoid cells. One of our cases, later diagnosed as marginal zone lymphoma, showed small lymphocytes with plasmacytoid features. Immunoprofiling information was available in five of our cases (three by immunocytochemistry and two by laser scanning cytometry) and in 34 reviewed cases (22 by immunocytochemistry, six by flow cytometry, and six by flow cytometry or immunocytochemistry). CONCLUSIONS: Cytological diagnosis of thyroid lymphoma requires careful analysis of morphological, clinical and immunophenotypic information. The presented data suggest certain helpful features: a fast-growing nodule in an elderly patient, a monotonous population of large abnormal cells in a background of lymphoglandular bodies, a predominant population of plasmacytoid lymphocytes, and immunophenotyping demonstrating light chain restriction.
Eric K Morgen; William Geddie; Scott Boerner; Denis Bailey; Gilda da Cunha Santos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  63     ISSN:  1472-4146     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  AIM; IM    
University Health Network and the University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Aged, 80 and over
Biopsy, Fine-Needle
Lymphoma, Non-Hodgkin / immunology,  pathology*
Middle Aged
Retrospective Studies
Thyroid Neoplasms / immunology,  pathology*

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