| The role of fibrinolytic system in no-reflow after stenting with and without predilation in patients with acute coronary syndromes: fibrinolysis and no-reflow after coronary stenting. | |
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MedLine Citation:
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PMID: 17294139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: No-reflow developed after coronary revascularization is an independent predictor of in-hospital mortality and poor clinical outcome. In this study, we investigated the difference between direct stenting and stenting with predilation, regarding to development of no-reflow in patients with acute coronary syndromes (ACS) and the role of fibrinolytic system in that phenomenon. METHODS: Fifty eight patients with the diagnosis of ACS in whom percutaneous coronary intervention (PCI) was applied were included in study. Patients were divided into two groups according to stent application with and without predilation. Pre- and post-intervention corrected TIMI frame counts (cTFC) were calculated. Post-PCI plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), plasminogen and D-Dimer levels were measured. RESULTS: Pre-intervention cTFC values were similar between stenting with and without predilation groups (P > 0.05). There was a significant decrease in post-intervention cTFC values in both groups (P < 0.002 and P < 0.05, respectively). But, there was no significant difference between post-intervention cTFC values of the groups, regardless to stent implantation techniques. (P > 0.05). In patients having high cTFC values compared with having low cTFC values; PAI-1 (P = 0.002), tPA (P = 0.015), plasminogen (P = 0.040) and D-dimer (P = 0.049) levels were significantly higher. Also, significant relationship was determined between cTFC and PAI-1, tPA, plasminogen, D-dimer levels (P values 0.003, <0.05, <0.05, and <0.002, respectively). CONCLUSIONS: Results of this study indicated an important role of increased fibrinolytic activity in development of no-reflow phenomenon after PCI. We didn't observe any differences between direct stenting and stenting with predilation according to the occurrence of no-reflow. |
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Authors:
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Sabri Demircan; Mustafa Yazici; Cavid Hamiseyev; Gunnur Demircan; Sevinc Sultansuyu; Erdogan Yasar; Mahmut Sahin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2007-02-10 |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 24 ISSN: 0929-5305 ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Ondokuz Mayis University Medical Faculty, 55139 Kurupelit, Samsun, Turkey. sabridemircan@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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physiopathology*,
therapy* Adult Aged Angioplasty, Balloon Biological Markers / blood Blood Coagulation Coronary Circulation* Dilatation* Female Fibrinolysis* Humans Male Middle Aged Myocardial Revascularization Prognosis Stents / adverse effects* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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