Document Detail

The role of the fibrinolytic system in acute myocardial infarction after a normal exercise test.
MedLine Citation:
PMID:  2514101     Owner:  NLM     Status:  MEDLINE    
A 67-year-old man had an acute myocardial infarction with thrombosis in the left anterior descending artery shortly after normal exercise. We were able to measure the fibrinolytic components in this patient just prior to his developing acute myocardial infarction as well as during convalescence. In this case, marked increase in total plasminogen activator inhibitor-1 (PAI-1) antigen, mainly due to free PAI-1 antigen, was observed in basal conditions before the onset of acute myocardial infarction. On the appearance of ischaemia, plasminogen activator activity was suppressed, probably due to decreased tissue plasminogen activator antigen release and increased PAI activity, compared with that during convalescence. This suggests that some patients with coronary artery disease who have a high level of free PAI-1 antigen in basal conditions may have a strong tendency to develop acute myocardial infarction, due to further impaired fibrinolysis on the induction of ischaemia.
K Sakata; C Kurata; T Taguchi; H Hayashi; A Kobayashi; N Yamazaki; A Rydzewski; A Takada
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  10     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1118-22     Citation Subset:  IM    
Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Acute Disease
Autoantigens / analysis
Exercise Test*
Myocardial Infarction / blood*,  physiopathology
Plasminogen Inactivators / blood,  immunology
Tissue Plasminogen Activator / blood*
Reg. No./Substance:
0/Autoantigens; 0/Plasminogen Inactivators; EC Plasminogen Activator

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