| The role of fibrinogen degradation products in the pathogenesis of the respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 918859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary dysfunction in awake rabbits was induced by intravenous infusion of a highly purified human fibrin split product (fragment D). The dose of infused fragment D was chosen to achieve observed plasma concentrations of fibrin split products in hospitalized patients with severe burns or trauma (about 100mug of FSP/ml of blood). Four hours after infusion, the animals displayed a clinical and pathological pattern which closely resembled post-traumatic acute respiratory distress syndrome, including hypoxia, hypocarbia, thrombocytopenia, increased pulmonary capillary permeability to albumin, interstitial edema, hypertrophy of alveolar lining cells, and intra-alveolar hemorrhage. In vivo production of fibrin split products by infusion of thrombin with induction of secondary fibrinolysis produced similar pulmonary changes, although intravascular clots and platelet aggregates also were prominent. Infusion of human fibrinogen and human albumin at identical doses failed to induce pulmonary dysfuction. The results suggest that fibrin split products (fragment D) alone are toxic to the respiratory system and may contribute to the development of acute respiratory distress syndrome in severely traumatized or burned patients. |
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Authors:
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A Luterman; D Manwaring; P W Curreri |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery Volume: 82 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1977 Nov |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 703-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / etiology Blood Platelets Burns / blood Carbon Dioxide / blood Female Fibrin Fibrinogen Degradation Products / pharmacology, physiology* Hemorrhage / etiology Humans Lung / pathology, physiopathology Male Oxygen / blood Pulmonary Edema / etiology Rabbits Respiratory Distress Syndrome, Adult / blood, complications, etiology*, pathology Thrombin / pharmacology, physiology |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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