Document Detail

The role of fibrinogen and CRP in cardiovascular risk in patients with acromegaly.
MedLine Citation:
PMID:  20205109     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Patients with active acromegaly have 2- to 3-fold increased cardiovascular mortality. Alterations of acute phase proteins, observed in acromegaly, could lead to cardiovascular diseases. Aim of the study was to evaluate fibrinogen and C-reactive protein (CRP) secretion in patients with acromegaly. MATERIAL AND METHODS: Seventy-seven patients were divided into groups with active (AA, n = 56) and controlled acromegaly (CA, n = 21). Twenty age- and sex-matched healthy subjects served as controls. Serum fibrinogen, CRP, fasting glucose, insulin, total cholesterol, LDL and HDL cholesterol, and triglycerides were measured, and body mass index (BMI) was calculated. RESULTS: Comparison between the groups revealed: higher fibrinogen, triglycerides, glucose levels, and BMI values in AA than in the controls; higher CRP, fibrinogen, triglyceride levels, and BMI values in CA than in the controls; higher LDL cholesterol and insulin levels and lower CRP levels and BMI values in the AA group than in the CA group. Fibrinogen concentration was highest in the AA group and lowest in the control group. Fibrinogen levels were high in all patients with acromegaly, irrespective of disease status, and they were significantly higher than in healthy subjects. CRP concentration was highest in the CA group and lowest in the control group. CRP levels were significantly and paradoxically lower in patients with AA than in patients with well-controlled disease and did not explain the increased cardiovascular mortality in acromegaly. CONCLUSIONS: Fibrinogen plays an important role as a cardiovascular risk factor in acromegaly, irrespective of the cure of the disease. The role of CRP as a cardiovascular risk factor in patients with uncontrolled acromegaly should be better explained in future studies. (Pol J Endocrinol 2010; 61 (1): 83-88).
Marcin Ka?uzny; Marek Bolanowski; Jacek Daroszewski; Andrzej Szuba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endokrynologia Polska     Volume:  61     ISSN:  0423-104X     ISO Abbreviation:  Endokrynol Pol     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370674     Medline TA:  Endokrynol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Department of Endocrinology, Diabetology, and Isotope Therapy, Medical University, Wroc?aw, Poland.
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MeSH Terms
Acromegaly / epidemiology*,  metabolism*
Acute-Phase Proteins / metabolism*
C-Reactive Protein / metabolism*
Cardiovascular Diseases / epidemiology*,  metabolism
Fibrinogen / metabolism*
Middle Aged
Risk Assessment
Reg. No./Substance:
0/Acute-Phase Proteins; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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