Document Detail

The role of the fetal gonads and placenta in steroid production, maintenance of pregnancy and parturition in the mare.
MedLine Citation:
PMID:  289829     Owner:  NLM     Status:  MEDLINE    
The effects of fetal gonadectomy on steroid production and the maintenance of pregnancy in the mare were studied. Removal of the fetal gonads resulted in an immediate fall in maternal plasma concentrations of conjugated and unconjugated oestrogens whereas progestagen levels remained unchanged. Hormone profiles in mares carrying sham-operated fetuses remained similar to those in unoperated control mares. Plasma levels of 13,14-dihydro-15-oxo-PGF-2 alpha (PGFM) were much lower, and uterine contractions weaker, during labour in mares carrying gonadectomized foals than in control mares. Pregnancy was maintained until parturition at term in the mares carrying gonadectomized fetuses. However, 3 of the 4 gonadectomized foals were dysmature and died during or soon after birth. The biosynthetic pathways involved in the production of oestrogens by the feto-placental unit and the possible role of oestrogens in fetal development in the pregnant mare are discussed.
R L Pashen; W R Allen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility. Supplement     Volume:  -     ISSN:  0449-3087     ISO Abbreviation:  J. Reprod. Fertil. Suppl.     Publication Date:  1979  
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0225652     Medline TA:  J Reprod Fertil Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-509     Citation Subset:  IM    
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MeSH Terms
Estrogens / blood
Gonads / embryology*,  physiology
Horses / physiology*
Labor, Obstetric*
Placenta / physiology*
Pregnancy Maintenance
Pregnancy, Animal*
Progestins / blood
Steroids / biosynthesis*
Reg. No./Substance:
0/Estrogens; 0/Progestins; 0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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