| The role of the fetal gonads and placenta in steroid production, maintenance of pregnancy and parturition in the mare. | |
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MedLine Citation:
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PMID: 289829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of fetal gonadectomy on steroid production and the maintenance of pregnancy in the mare were studied. Removal of the fetal gonads resulted in an immediate fall in maternal plasma concentrations of conjugated and unconjugated oestrogens whereas progestagen levels remained unchanged. Hormone profiles in mares carrying sham-operated fetuses remained similar to those in unoperated control mares. Plasma levels of 13,14-dihydro-15-oxo-PGF-2 alpha (PGFM) were much lower, and uterine contractions weaker, during labour in mares carrying gonadectomized foals than in control mares. Pregnancy was maintained until parturition at term in the mares carrying gonadectomized fetuses. However, 3 of the 4 gonadectomized foals were dysmature and died during or soon after birth. The biosynthetic pathways involved in the production of oestrogens by the feto-placental unit and the possible role of oestrogens in fetal development in the pregnant mare are discussed. |
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Authors:
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R L Pashen; W R Allen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of reproduction and fertility. Supplement Volume: - ISSN: 0449-3087 ISO Abbreviation: J. Reprod. Fertil. Suppl. Publication Date: 1979 |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0225652 Medline TA: J Reprod Fertil Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 499-509 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Castration Estrogens / blood Female Gonads / embryology*, physiology Horses / physiology* Labor, Obstetric* Male Placenta / physiology* Pregnancy Pregnancy Maintenance Pregnancy, Animal* Progestins / blood Steroids / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Progestins; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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