Document Detail

The role of fatty acids in the treatment of ADHD.
MedLine Citation:
PMID:  19715711     Owner:  NLM     Status:  MEDLINE    
Several arguments have been proposed to support the hypothesis that supplementation with essential fatty acids (EFAs) could be valuable in the treatment of attention deficit-hyperactivity disorder (ADHD). Indeed, this disorder seems to involve the monoaminergic systems which have been shown to be affected by polyunsaturated fatty acid (PUFA) status, at least in animal models. In addition, several studies have reported abnormal nutritional status with regard to EFAs in ADHD, indicating that lower levels of long-chain PUFAs occur more frequently in the plasma and/or red blood cells of ADHD subjects. Few nutritional EFA supplementation studies have been reported in ADHD to date, but several of them have shown increased blood EFA levels, although their effects on ADHD-related symptoms were not or were only partly successful. The current findings have not yet been clearly proved and require further investigation.
Sylvie Chalon
Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-26
Journal Detail:
Title:  Neuropharmacology     Volume:  57     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  636-9     Citation Subset:  IM    
UMR Inserm U930, CNRS ERL3106, Universit? Fran?ois Rabelais, UFR Pharmacie, 31 avenue Monge, 37200 Tours, France.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / diet therapy*,  metabolism,  physiopathology
Brain / metabolism,  physiopathology
Dietary Supplements
Fatty Acids, Unsaturated / physiology,  therapeutic use*
Reg. No./Substance:
0/Fatty Acids, Unsaturated

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