Document Detail


The role of Rhox homeobox factors in tumorigenesis.
MedLine Citation:
PMID:  23276937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homeobox genes encode transcription factors that have well-established roles in embryonic development. We recently discovered the Rhox genes, a new family of homeobox genes, which are selectively expressed in the developing embryo, postnatal and adult gonads, and accessory tissues associated with mammalian reproduction. The largest and best-characterized Rhox cluster is found in mouse. However, all mammals examined to date possess a set of Rhox genes that, while they may vary in number by species, appear relevant to reproduction and are located in the syntenic region of the X chromosome. Rhox5, the founding member of the family, was initially cloned from a screen to identify tumorigenic antigens from T-cell lymphomas, and was later found to be widely expressed in tumors from tissues of diverse origins that do not normally express the Rhox genes. This aberrant upregulation appears to be a general feature of many Rhox genes, but the implications of this misexpression remain largely uninvestigated. In this review, we will discuss the latest findings on the normal and abnormal roles of the Rhox genes and their potential contributions to the formation and progression of tumors.
Authors:
James A MacLean
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-92     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, Southern Illinois University 1135 Lincoln Drive, Carbondale, IL 62901, USA. jmaclean@siumed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle Proteins / metabolism
Cell Differentiation / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Cell Transformation, Neoplastic / genetics*
Chaperonins / metabolism
Epididymis / metabolism
Epigenesis, Genetic
Evolution, Molecular
Female
Homeodomain Proteins / genetics*,  physiology
Humans
Lymphoma, T-Cell / metabolism
Male
Mice
Ovary / metabolism
Proto-Oncogene Proteins / metabolism
Saposins / metabolism
Testis / metabolism
Transcription Factors / genetics*,  physiology
X Chromosome / genetics
Grant Support
ID/Acronym/Agency:
HD065584/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/CDC37 protein, human; 0/Cell Cycle Proteins; 0/Homeodomain Proteins; 0/MEN1 protein, human; 0/PSAP protein, human; 0/Proto-Oncogene Proteins; 0/Saposins; 0/Transcription Factors; EC 3.6.1.-/Chaperonins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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