| The role of Rhox homeobox factors in tumorigenesis . | |
| | |
MedLine Citation:
|
PMID: 23276937 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Homeobox genes encode transcription factors that have well-established roles in embryonic development. We recently discovered the Rhox genes, a new family of homeobox genes, which are selectively expressed in the developing embryo, postnatal and adult gonads, and accessory tissues associated with mammalian reproduction. The largest and best-characterized Rhox cluster is found in mouse. However, all mammals examined to date possess a set of Rhox genes that, while they may vary in number by species, appear relevant to reproduction and are located in the syntenic region of the X chromosome. Rhox5, the founding member of the family, was initially cloned from a screen to identify tumorigenic antigens from T-cell lymphomas, and was later found to be widely expressed in tumors from tissues of diverse origins that do not normally express the Rhox genes. This aberrant upregulation appears to be a general feature of many Rhox genes, but the implications of this misexpression remain largely uninvestigated. In this review, we will discuss the latest findings on the normal and abnormal roles of the Rhox genes and their potential contributions to the formation and progression of tumors. |
| | |
Authors:
|
James Arthur Maclean Ii |
Related Documents
:
|
22951807 - Actin capping proteins, capz (β-actinin) and tropomodulin in amphioxus striated muscle. 23637227 - Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epider... 16733717 - Diversity of killer cell immunoglobulin-like receptor genes in pacific islands populati... 23072467 - Identification and characterization of the chaetoviridin and chaetomugilin gene cluster... 19136467 - Structure and expression analysis of rice paleo duplications. 22639297 - Bmp-2 and tgf-β3 do not prevent spontaneous degeneration in rabbit disc explants but i... |
Publication Detail:
|
Type: Journal Article Date: 2013-01-01 |
Journal Detail:
|
Title: Frontiers in bioscience : a journal and virtual library Volume: 18 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2013 |
Date Detail:
|
Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
|
Languages: eng Pagination: 474-92 Citation Subset: IM |
Affiliation:
|
Department of Physiology, School of Medicine, Southern Illinois University 1135 Lincoln Drive, Carbondale IL 62901. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biological significance and targeting of c-Met tyrosine kinase receptor in cancer .
Next Document: WNT3A modulates chondrogenesis via canonical and non-canonical Wnt pathways in MSCs .