| The role of f-fluorodeoxyglucose positron emission tomography in the treatment of brain abscess. | |
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MedLine Citation:
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PMID: 21716900 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to evaluate whether (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used to assess the therapeutic response of brain abscess. METHODS: A study was conducted on 10 consecutive patients with brain abscess. Magnetic resonance imaging (MRI) with diffuse-weighted imaging (DWI) was performed at 3 and 6 weeks after surgical treatment and intravenous antibiotics therapy and FDG-PET at 6 weeks after treatment. The extent of the abscess, signal changes on MRI, and FDG-PET standardized uptake values were analyzed and correlated with the response to therapy. RESULTS: Aspiration or craniotomy with excision of the abscess followed by intravenous antibiotics for 6-8 weeks resulted in good recovery with no recurrence. In 10 patients, two had low signal intensity on the DWI; one had no uptake on FDG-PET imaging after 6 weeks antibiotics and discontinued intravenous treatment, but the other patient had diffuse, increased uptake on FDG-PET imaging after 6 weeks antibiotics and underwent an additional 2 weeks of intravenous antibiotics. The remaining eight patients had high signals on the DWI. Four had no uptake on FDG-PET imaging and the treatment period varied from 6 to 8 weeks (mean, 6.75 weeks). Among the other four patients, FDG was accumulated in a diffuse or local area corresponding to a high signal area within the DWI and 2 weeks of intravenous antibiotics was added. CONCLUSION: MRI plus FDG-PET improved the accuracy of assessing therapeutic responses to antibiotics treatment of brain abscess and aided in optimizing therapy. |
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Authors:
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Seong-Hyun Park; Sang-Woo Lee; Dong-Hun Kang; Jeong-Hyun Hwang; Joo-Kyung Sung; Sung-Kyoo Hwang |
Publication Detail:
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Type: Journal Article Date: 2011-05-31 |
Journal Detail:
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Title: Journal of Korean Neurosurgical Society Volume: 49 ISSN: 1598-7876 ISO Abbreviation: J Korean Neurosurg Soc Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-06-30 Completed Date: 2011-07-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101467054 Medline TA: J Korean Neurosurg Soc Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 278-83 Citation Subset: - |
Affiliation:
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Department of Neurosurgery, Kyungpook National University Hospital, Daegu, Korea. |
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