Document Detail

The role of extracellular sodium in the mechanism of a neuronal in vitro circadian pacemaker.
MedLine Citation:
PMID:  9042546     Owner:  NLM     Status:  MEDLINE    
In evaluation of whether extracellular ion concentrations or fluxes are involved in the mechanism of the circadian pacemaker in Bulla retinal neurons, previous studies have ruled out obligatory requirements for extracellular calcium and chloride. In this study, it is demonstrated that extracellular sodium and magnesium are also not requirements for and do not contribute to the circadian pacemaker mechanism. Since sodium-free solutions inhibit the output rhythm of compound action potential activity, pacemaker motion during long pulse treatments was evaluated retrospectively from the phase of the circadian rhythm subsequent to the treatment. Although some pulses of sodium-free solutions were capable of affecting pacemaker phase in a manner consistent with the stopping of pacemaker motion, these effects were reversed by elevating extracellular pH, suggesting that sodium-free solutions can only affect pacemaker motion indirectly through a previously demonstrated effect of low pH on pacemaker motion.
S B Khalsa; S Michel; G D Block
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chronobiology international     Volume:  14     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-06-02     Completed Date:  1997-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
NSF Center for Biological Timing, Department of Biology, Charlottesville, Virginia 22901, USA.
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MeSH Terms
Action Potentials
Cell Membrane / metabolism
Circadian Rhythm / physiology*
Extracellular Space / metabolism
Hydrogen-Ion Concentration
Ion Transport
Magnesium / metabolism
Neurons / metabolism*
Optic Nerve / metabolism
Retina / metabolism
Sodium / metabolism*
Grant Support
Reg. No./Substance:
0/Solutions; 7439-95-4/Magnesium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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