Document Detail

The role of estrogen in the maintenance of primate pregnancy.
MedLine Citation:
PMID:  10694348     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the role of estrogen in pregnancy maintenance in baboons by suppressing estrogen synthesis through administration of a highly specific nonsteroidal aromatase inhibitor, CGS 20267. STUDY DESIGN: CGS 20267 was administered subcutaneously at maximal dosages of 2.0 mg/d to pregnant baboons (n = 24) daily beginning on either day 30 (n = 8), day 60 (n = 8), or day 100 (n = 8) of gestation (normal length of gestation is 184 days) until animals miscarried or were delivered abdominally on days 160 through 168 of gestation. CGS 20267 and estradiol (n = 9), each at maximal dosages of 2 mg/d, were administered at the same intervals of gestation. Twenty baboons served as untreated control animals. Serum estradiol and progesterone levels were determined by radioimmunoassay from serum samples obtained at 1- to 3-day intervals from a maternal peripheral vein. RESULTS: Within 1 to 3 days of the initiation of CGS 20267 administration, maternal serum estradiol concentration decreased to and remained at a level that was substantially lower (mean +/- SE, 0. 096 +/- 0.003 ng/mL) than in the untreated control animals throughout gestation (0.35-4.0 ng/mL; P <.001). Although pregnancy was maintained in 19 of the 20 untreated control baboons (95%), only 12 of the 24 animals that received CGS 20267 (50%) maintained pregnancy. In contrast, all the baboons treated concomitantly with estradiol and CGS 20267 (9/9) maintained pregnancy. Thus estradiol alone prevented the high rate of miscarriage induced by the antiestrogenic agent CGS 20267. Serum progesterone concentrations were not significantly different throughout the experimental period between the CGS 20267-treated baboons that maintained pregnancy (12. 9 +/- 1.4 ng/mL) and those that miscarried (13.6 +/- 1.6 ng/mL) and were not lower in antiestrogen-treated baboons than in untreated control baboons (10.6 +/- 0.8 ng/mL). CONCLUSION: Estrogen, acting directly, indirectly, or both through a factor or factors other than the level of progesterone, plays a critically important physiologic role in the maintenance of primate pregnancy.
E D Albrecht; G W Aberdeen; G J Pepe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  182     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-21     Completed Date:  2000-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  432-8     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Studies in Reproduction, the University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Aromatase Inhibitors*
Cesarean Section / veterinary
Chemiluminescent Measurements
Enzyme Inhibitors / pharmacology*
Estradiol / blood,  pharmacology,  physiology*
Nitriles / pharmacology*
Papio / physiology*
Pregnancy, Animal / drug effects,  physiology*
Progesterone / blood
Radioimmunoassay / veterinary
Random Allocation
Triazoles / pharmacology*
Grant Support
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Enzyme Inhibitors; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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