| The role of essential metals in the placental transfer of lead from mother to child. | |
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MedLine Citation:
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PMID: 20347956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have found adverse birth and child health outcomes from prenatal lead exposure, but little is known about factors influencing placental transfer. In this study we describe the placental transfer of lead in a Taiwanese population, and investigate whether three essential metals - zinc, manganese, or selenium - influence transfer. Maternal and cord blood samples (308 pairs) from a birth cohort study were analyzed using multiple linear regression. There was a clear correlation between mother and child lead concentration (r=0.48, p<0.001), although lead concentration in cord blood (mean=1.29, SD=0.72 microg/dL) was lower than that for mothers (mean=1.58, SD=1.11 microg/dL). Cord blood lead was lower where the mother had a higher blood concentration of zinc (p<0.001) or manganese (p=0.02). Thus maternal blood zinc and manganese, but not selenium, appeared to decrease the placental transfer of lead. These findings raise the possibility of reducing placental transfer of lead by increasing zinc levels via nutritional supplementation during pregnancy. |
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Authors:
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Chien-Mu Lin; Pat Doyle; Duolao Wang; Yaw-Huei Hwang; Pau-Chung Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-27 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 29 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 443-6 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Sectional Studies Female Fetal Blood / chemistry Humans Infant, Newborn Lead / blood, pharmacokinetics* Magnesium / blood, pharmacokinetics Maternal Exposure* Maternal-Fetal Exchange* Placenta / metabolism* Pregnancy Selenium / blood, pharmacokinetics Taiwan Trace Elements / blood, pharmacokinetics* Zinc / blood, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Trace Elements; 7439-92-1/Lead; 7439-95-4/Magnesium; 7440-66-6/Zinc; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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