Document Detail


The role of esophageal motility and hiatal hernia in esophageal exposure to acid.
MedLine Citation:
PMID:  12163954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The pathogenesis of gastroesophageal reflux disease (GERD) is multifactorial. This study evaluates the relationship between esophageal exposure to acid, the presence or absence of a hiatal hernia, and manometric indicators of esophageal motility. METHODS: A total of 51 patients with foregut symptoms were evaluated with upper gastrointestinal series or endoscopy, 24-h pH testing, and esophageal manometry. The DeMeester score was used to distinguish patients with physiologic reflux (DeMeester score <14.72) patients with pathologic reflux (DeMeester score >14.72). RESULTS: Patients with physiologic reflux had fewer hypotensive contractions and a smaller percentage of uncoordinated and hypotensive contractions combined, as compared to patients with pathologic reflux. The amplitude of distal esophageal contractions was greater in patients with physiologic reflux. Also, patients with a hiatal hernia had a higher incidence of pathologic reflux, regardless of the lower esophageal sphincter pressure. CONCLUSION: Patients with pathologic reflux have abnormal acid exposure associated with pump failure of the esophagus and/or a mechanical defect of the cardia associated with a hiatal hernia.
Authors:
E S Xenos
Related Documents :
20198424 - Management of recurrence of symptoms of gastroesophageal reflux disease: synergistic ef...
11700474 - Most incompetent calf perforating veins are found in association with superficial venou...
7025214 - The evaluation of gastroesophageal reflux before and after medical therapies.
15718864 - Ineffective esophageal motility in gastroesophageal erosive reflux disease and in noner...
19796534 - Elevated levels of mmp-9 and timp-1 in the cerebrospinal fluid of neuro-beh??et's disease.
2326834 - Carotid transient ischemic attacks and normal investigations: a follow-up study.
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2002-02-27
Journal Detail:
Title:  Surgical endoscopy     Volume:  16     ISSN:  1432-2218     ISO Abbreviation:  Surg Endosc     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-08-06     Completed Date:  2002-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8806653     Medline TA:  Surg Endosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  914-20     Citation Subset:  IM    
Affiliation:
Department of Surgery, Lincoln County Memorial Center, 1000E Cherry Street, Troy, MO 63379, USA. lxenos@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Esophagus / physiopathology
Female
Gastric Acid
Gastroesophageal Reflux / etiology*,  physiopathology
Gastroscopy
Hernia, Hiatal / complications*
Humans
Hydrogen-Ion Concentration
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Total fundoplication is the operation of choice for patients with gastroesophageal reflux and defect...
Next Document:  Ambulatory and admitted laparoscopic cholecystectomy patients have comparable outcomes but different...