| The role of epithelial beta-defensins and cathelicidins in host defense of the lung. | |
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MedLine Citation:
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PMID: 18075828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The continuous exposure of the epithelial surface of the conducting airways to inhaled pathogens requires the presence of an efficient innate immune system to prevent infections. The innate immune system of the lung provides protection against a broad spectrum of microbial threats through a variety of effector mechanisms. The antimicrobial peptides and proteins form important elements of this defence system in the lung. Defensins and cathelicidins are the main families of antimicrobial peptides (AMPs) that are present in airway secretions and that are expressed by the airway epithelium. Expression and release of these small (3-5 kDa) cationic peptides is regulated by exposure of epithelial cells to a wide variety of substances, including microbial products, cytokines and growth factors. More recently, also active vitamin D(3) has been implicated as a major regulator of AMPs expression. AMPs contribute to host defence through direct antimicrobial activity, as well as by modulating innate and adaptive immunity, and wound repair. Novel insight into the mechanism of action of these peptides and the regulation of their expression may lead to innovative approaches for treatment of infectious and inflammatory lung disorders. |
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Authors:
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Pieter S Hiemstra |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experimental lung research Volume: 33 ISSN: 0190-2148 ISO Abbreviation: Exp. Lung Res. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-02-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: United States |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Affiliation:
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Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands. p.s.hiemstra@lumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cathelicidins
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physiology* Humans Immunity, Innate / physiology Lung / immunology* Lung Diseases / immunology Respiratory Mucosa / immunology beta-Defensins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Cathelicidins; 0/beta-Defensins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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