Document Detail


The role of enzymatic antioxidants detected in the follicular fluid and semen of infertile couples undergoing assisted reproduction.
MedLine Citation:
PMID:  19925327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The follicular fluid environment surrounding the oocytes may play a critical role in fertilization and subsequent embryo development. The goal of our study was to evaluate the oxidative stress markers in the semen, blood serum, and follicular fluid of couples undergoing Intracytoplasmic Sperm Injection (ICSI). Two hundred and eight infertile couples underwent ICSI and the levels of superoxide dismutase (SOD) and catalase and lipid peroxidation (LPO) were evaluated. Semen Catalase was highly correlated with fertilization and cleavage rates, but not with pregnancy rates. Fertilization and cleavage rates were correlated with the levels of SOD and Catalase in the follicular fluid. After adjusting for age, a negative correlation was detected between LPO levels in follicular fluid and pregnancy rates. Follicular fluid LPO levels may be a marker as a metabolic activity within the follicle need for establishing a pregnancy.
Authors:
Eleonora Bedin Pasqualotto; Luana Venturin Lara; Mirian Salvador; Bernardo Passos Sobreiro; Edson Borges; F??bio Firmbach Pasqualotto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human fertility (Cambridge, England)     Volume:  12     ISSN:  1742-8149     ISO Abbreviation:  Hum Fertil (Camb)     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888143     Medline TA:  Hum Fertil (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  166-71     Citation Subset:  IM    
Affiliation:
University of Caxias do Sul, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Analysis of Variance
Catalase / metabolism*
Embryo Transfer
Female
Fertilization in Vitro
Follicular Fluid / metabolism*
Humans
Infertility / metabolism*,  therapy
Lipid Peroxidation
Male
Pregnancy
Pregnancy Rate
Semen / metabolism*
Sperm Injections, Intracytoplasmic
Superoxide Dismutase / metabolism*
Chemical
Reg. No./Substance:
EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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