Document Detail

The role of endotoxin in the pathogenesis of experimental multiple system organ failure: a preliminary report.
MedLine Citation:
PMID:  1286184     Owner:  NLM     Status:  MEDLINE    
In this study, an animal model of multiple system organ failure (MSOF) in rabbits, engendered by feeding E. coli prior to severe hemorrhagic shock, was used for the purpose of investigating 1) the relationship between lipopolysaccharide (LPS) and MSOF, and 2) the effectiveness of Re-LPS antiserum in preventing MSOF. The results showed that endotoxemia occurred very early, and its degree correlated well with that of organ dysfunction. Re-LPS antiserum administration abated the toxic effects and lowered the incidence of MSOF. These results suggest that sequential analysis of circulating LPS levels may be useful for the early diagnosis of MSOF, and that gut-derived endotoxin might play an important role in the pathogenesis of experimental MSOF.
Y Yao; H Tian; Z Sheng; Y P Wang; Z Shi; F Lan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  7     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Trauma Research Center, Postgraduate Medical College, 304th Hospital of PLA, Beijing.
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MeSH Terms
Endotoxins / toxicity*
Escherichia coli*
Immunization, Passive
Lipopolysaccharides / blood,  immunology
Multiple Organ Failure / etiology*,  prevention & control
Shock, Hemorrhagic / complications
Reg. No./Substance:
0/Endotoxins; 0/Lipopolysaccharides

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