Document Detail

The role of endothelium-derived mediators in exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  17356298     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition whose pathogenesis and effect on airways remain unclear. The aim of the study was to evaluate the changes in endothelial-derived mediators following intensive exercise in asthmatic patients. METHODS: The study was conducted in a group of 25 asthmatic patients (15 with EIB, 10 without EIB) and 8 healthy volunteers. Changes induced by intensive exercise in the plasma concentrations of endothelin-1 (ET-1), thrombomodulin and soluble E-selectin were determined. Moreover, the possible correlations of these measurements with the results of baseline lung function, bronchial hyperreactivity (BHR), exhaled nitric oxide (F(ENO)), baseline eosinophil cationic protein, peripheral blood eosinophilia and total IgE were investigated. RESULTS: In the group of asthmatics with EIB, statistically significantly higher baseline concentrations of ET-1 and soluble E-selectin compared with asthmatics with negative exercise test results were revealed. In this group of patients, ET-1, thrombomodulin and soluble E-selectin concentrations significantly increased after exercise. Baseline concentrations of ET-1 as well as an increase in soluble E-selectin concentrations 60 min after exercise showed a statistically significant correlation with baseline eosinophil cationic protein, F(ENO) and BHR. The increase in plasma concentrations of ET-1 15 min after exercise and soluble E-selectin 60 min after exercise showed a statistically significant correlation with the increase in F(ENO) and BHR to histamine 24 h after exercise. CONCLUSIONS: We suggest that during EIB changes in the function of pulmonary endothelium occur and these changes may influence inflammation of the airway and remodeling in asthmatic patients.
Ziemowit Zietkowski; Anna Bodzenta-Lukaszyk; Maria Magdalena Tomasiak; Roman Skiepko; Maciej Szmitkowski; Barbara Mroczko
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Publication Detail:
Type:  Journal Article     Date:  2007-03-14
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  143     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-13     Completed Date:  2007-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  299-310     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Department of Allergology, Medical University of Bialystok, Bialystok, Poland.
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MeSH Terms
Asthma, Exercise-Induced / immunology,  metabolism*,  physiopathology
Endothelium / immunology,  physiology*,  physiopathology
Inflammation Mediators / physiology*
Respiratory Mucosa / immunology,  metabolism*,  physiology*
Reg. No./Substance:
0/Inflammation Mediators

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