| The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 21419223 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The term pulmonary arterial hypertension (PAH) describes a rare group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles (<100mM). Left untreated, patients die from right heart failure, with a mortality approaching most serious cancers. Endothelin-1(ET-1) is not only a potent vasoconstrictor, but causes proliferation of many of the vascular cells involved in vascular remodelling. Although produced mainly by the vascular endothelium, other cells such as smooth muscle, fibroblasts and macrophages are known sources of ET-1 when these cells are challenged by relevant stimuli. Plasma ET-1 levels are raised in patients with PAH and correlate with important clinical outcomes. Furthermore, ET-1 receptor antagonism has been demonstrated to improve both morbidity and mortality in conditions associated with PAH. We review the literature supporting the role for ET-1 in the pathogenesis of PAH. |
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Authors:
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Dongmin Shao; John Es Park; Stephen J Wort |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: - ISSN: 1096-1186 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Adult Intensive Care Unit, Royal Brompton Hospital, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LY, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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