Document Detail

The role of endothelin-1 in human hypertension.
MedLine Citation:
PMID:  17641406     Owner:  NLM     Status:  MEDLINE    
Endothelin-1 (ET-1) is a powerful vasoconstrictor and mitogen that contributes to blood pressure elevation and related vascular remodeling and target organ damage. ET-1 also influences salt and water homeostasis through effects on the renin-angiotensin-aldosterone system and vasopressin, thus elevating blood pressure and increasing vascular tone. Circulating ET-1 levels are elevated in a variety of animal models of hypertension, particularly those that are salt-dependent, and in a subset of human hypertensives, i.e. African-Americans and those with renal dysfunction. ET type B receptors, which normally have vasodilator functions, mediate vasoconstriction in some hypertensives, and hypertensive African-American patients may have increased numbers of vasoconstrictor ET-B receptors in their vascular smooth muscle. Whether selective ET-A or combined ET-A/ET-B receptor antagonists are more efficacious in treating hypertension and related cardiovascular disease is controversial. ET antagonists have only modest BP lowering effects in the general population of essential hypertensives, but show promise in patients with severe, treatment resistant hypertension.
Satya Shreenivas; Suzanne Oparil
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  37     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-20     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  157-78     Citation Subset:  IM    
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Endothelin-1 / antagonists & inhibitors*,  physiology*
Heart Diseases / drug therapy,  etiology
Hypertension / complications,  drug therapy,  etiology*
Kidney Tubules
Receptors, Endothelin
Reg. No./Substance:
0/Endothelin-1; 0/Receptors, Endothelin

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