Document Detail

The role of endogenous opiates in the area postrema pressor pathway.
MedLine Citation:
PMID:  7449268     Owner:  NLM     Status:  MEDLINE    
1. Intra-vertebral artery-administered angiotensin II acts at the area postrema to facilitate central sympathetic vasomotor activity. Recent evidence suggests a possible role of the opiate system in the mechanism of action of angiotensin II at the level of the brain stem. 2. In these experiments, we show that the morphine antagonist naloxone reduces significantly the magnitude of the pressor response to vertebral artery-infused angiotensin II. 3. Morphine, in contrast, doubled the peak of the vertebral response to identical doses of the peptide. Neither naloxone nor morphine affected the pressor responses to intravenously administered angiotensin II. 4. The data suggest that the endogenous opiate system in the medulla modulates the cardiovascular effects of angiotensin II at the level of the area postrema.
J E Szilagyi; C M Ferrario
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  59 Suppl 6     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  267s-269s     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / pharmacology,  physiology
Blood Pressure* / drug effects
Cerebral Ventricles / physiology*
Endorphins / physiology*
Heart Rate / drug effects
Morphine / pharmacology
Naloxone / pharmacology
Grant Support
Reg. No./Substance:
0/Endorphins; 11128-99-7/Angiotensin II; 465-65-6/Naloxone; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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