| The role of electrical signaling via gap junctions in the generation of fast network oscillations. | |
| | |
MedLine Citation:
|
PMID: 14596887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In recent years, several key studies have shed new light on the roles of electrical signaling via gap junctions between neurons in the adult brain. In particular, it is now clear that electrical signaling is important, if not essential, for the generation of a wide variety of different network interactions which may underlie rhythmic activity, of cognitive relevance, seen in EEG recordings. Two types of such rhythmic activity observed in the hippocampus both in vivo and in vitro are gamma frequency (30-80Hz) oscillations and ultrafast (>80Hz) "ripple" oscillations. Several lines of work, discussed here, show that gap junction-mediated signaling plays a central role in the generation of both these types of network activity. Recent work also now suggests that a number of different, anatomically discrete, gap junction-mediated networks may exist which could both function and be modulated independently. |
| | |
Authors:
|
Fiona E N LeBeau; Roger D Traub; Hannah Monyer; Miles A Whittington; Eberhard H Buhl |
Related Documents
:
|
744827 - Loudness of complex sounds as a function of the standard stimulus and the number of com... 20721017 - Improvement of delay-bandwidth product in photonic crystal slow-light waveguides. 21140217 - Changes in antenna of photosystem ii induced by short-term heating. 12633367 - Light transport through the band-edge states of fibonacci quasicrystals. 16657847 - Correlation between polyribosome level and the ability to induce nitrate reductase in d... 16182597 - The preparation and in vivo applications of caged peptides and proteins. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Brain research bulletin Volume: 62 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-11-04 Completed Date: 2004-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: United States |
Other Details:
|
Languages: eng Pagination: 3-13 Citation Subset: IM |
Affiliation:
|
School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK. F.E.N.LeBeau@leeds.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Connexins / metabolism Cortical Synchronization* Electric Conductivity Electroencephalography Gap Junctions / physiology* Hippocampus / cytology, physiology Humans Models, Neurological Nerve Net / physiology* Neurons / classification, physiology* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Connexins; 0/connexin 36 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tetraspanins: molecular organisers of the leukocyte surface.
Next Document: The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.