| The role of eicosanoids and endothelium-dependent factors in regulation of the fetal pulmonary circulation. | |
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MedLine Citation:
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PMID: 8358006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A complex interaction of mechanical, hormonal, vasoactive, morphological and gaseous factors is responsible for the transitional period and maintenance of these changes in the newborn period. Vasoactive eicosanoids, formed at multiple sites in the lungs exert multiple effects on the perinatal pulmonary circulation. By direct, as well as indirect interaction with other systems, eicosanoids appear to have a role in the rearrangement of the circulation at birth. At this time PGE1, acetylcholine, bradykinin, and endothelin appears to work, at least in part, to cause fetal pulmonary vasodilation via the release of EDRF. Products of the lipoxygenase pathway are powerful vasoconstrictors, but may not be important in regulation of high fetal pulmonary vascular tone or the pulmonary pressor response to hypoxia. |
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Authors:
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S Cassin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of lipid mediators Volume: 6 ISSN: 0921-8319 ISO Abbreviation: J Lipid Mediat Publication Date: 1993 Mar-Apr |
Date Detail:
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Created Date: 1993-09-24 Completed Date: 1993-09-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8913460 Medline TA: J Lipid Mediat Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 477-85 Citation Subset: IM |
Affiliation:
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Department of Physiology, College of Medicine, University of Florida, Gainesville 32610-0274. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Eicosanoids / physiology Endothelins / physiology Fetus / physiology* Nitric Oxide / physiology Pulmonary Circulation / physiology* Sheep Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 0/Endothelins; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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