Document Detail


The role of early life viral bronchiolitis in the inception of asthma.
MedLine Citation:
PMID:  23385289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RECENT FINDINGS: Recent studies have supported the long-recognized link between early life severe respiratory syncytial virus bronchiolitis and the physician diagnosis of asthma by school age, and this association appears to continue into early adulthood. Evidence is accumulating regarding the role of early life infection with human rhinovirus as an important antecedent for future asthma. Whether viral bronchiolitis is causal or an early manifestation of future asthma remains uncertain. Vitamin D status has emerged as a potential modifying factor for viral-induced wheeze and could potentially influence the development of asthma.
SUMMARY: Viral bronchiolitis early in life is a major and potential long-term risk factor for subsequent wheezing and asthma. Whether the association between bronchiolitis and subsequent asthma is due to causality or a reflection of predisposition may be dependent on host factors and virus-specific effects.
Authors:
Avraham Beigelman; Leonard B Bacharier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  13     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-08-12     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Asthma / etiology*
Bronchiolitis, Viral / complications*
Child
Genetic Predisposition to Disease
Humans
Risk Factors
Grant Support
ID/Acronym/Agency:
KL2 TR000450/TR/NCATS NIH HHS; KL2 TR000450/TR/NCATS NIH HHS; R01 HL092486/HL/NHLBI NIH HHS; UL1 TR000448/TR/NCATS NIH HHS; UL1 TR000448/TR/NCATS NIH HHS
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