Document Detail


The role of dynamin in HIV type 1 Env-mediated cell-cell fusion.
MedLine Citation:
PMID:  21338326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV-1 envelope glycoproteins are the key viral proteins that mediate HIV-1 entry and cell-cell fusion. In contrast to HIV-1 entry, the mechanism of HIV-1 Env-mediated cell-cell fusion is relatively unclear. This study demonstrated that dynasore, a dynamin inhibitor, suppressed HIV-1 Env-mediated cell-cell fusion. Dynasore sensitivity of HIV-1 Env-mediated cell-cell fusion varied depending on the viral strains. Results from testing a panel of gp41 cytoplasmic tail truncation mutants suggested that the gp41 cytoplasmic tail might play a role in dynasore sensitivity. HIV-1 Env-mediated cell-cell fusion could also be suppressed by a dynamin dominant-negative mutant DNM2(K44A). In summary, these results suggested that dynamin 2 might play a role in HIV-1 Env-mediated cell-cell fusion.
Authors:
Weihong Lai; Li Huang; Phong Ho; David Montefiori; Chin-Ho Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-23
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  27     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-24     Completed Date:  2011-12-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1013-7     Citation Subset:  IM; X    
Affiliation:
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Fusion*
Dynamin II / antagonists & inhibitors,  metabolism*
HIV-1 / pathogenicity*
Host-Pathogen Interactions*
Hydrazones / metabolism
env Gene Products, Human Immunodeficiency Virus / metabolism
Chemical
Reg. No./Substance:
0/Hydrazones; 0/N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide; 0/env Gene Products, Human Immunodeficiency Virus; EC 3.6.5.5/Dynamin II
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