| The role of dynamin in HIV type 1 Env-mediated cell-cell fusion. | |
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MedLine Citation:
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PMID: 21338326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HIV-1 envelope glycoproteins are the key viral proteins that mediate HIV-1 entry and cell-cell fusion. In contrast to HIV-1 entry, the mechanism of HIV-1 Env-mediated cell-cell fusion is relatively unclear. This study demonstrated that dynasore, a dynamin inhibitor, suppressed HIV-1 Env-mediated cell-cell fusion. Dynasore sensitivity of HIV-1 Env-mediated cell-cell fusion varied depending on the viral strains. Results from testing a panel of gp41 cytoplasmic tail truncation mutants suggested that the gp41 cytoplasmic tail might play a role in dynasore sensitivity. HIV-1 Env-mediated cell-cell fusion could also be suppressed by a dynamin dominant-negative mutant DNM2(K44A). In summary, these results suggested that dynamin 2 might play a role in HIV-1 Env-mediated cell-cell fusion. |
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Authors:
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Weihong Lai; Li Huang; Phong Ho; David Montefiori; Chin-Ho Chen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-23 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: 27 ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-24 Completed Date: 2011-12-16 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: United States |
Other Details:
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Languages: eng Pagination: 1013-7 Citation Subset: IM; X |
Affiliation:
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Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Fusion* Dynamin II / antagonists & inhibitors, metabolism* HIV-1 / pathogenicity* Host-Pathogen Interactions* Hydrazones / metabolism env Gene Products, Human Immunodeficiency Virus / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hydrazones; 0/N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide; 0/env Gene Products, Human Immunodeficiency Virus; EC 3.6.5.5/Dynamin II |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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