Document Detail

The role of ductal constriction in transient stenosis of the left pulmonary artery.
MedLine Citation:
PMID:  9568221     Owner:  NLM     Status:  MEDLINE    
To confirm the hypothesis that narrowing of the left pulmonary artery is produced by ductal closure, Doppler velocities in the pulmonary arteries from 20 premature infants with a patent duct were compared to velocities from 20 with a closed duct. In infants with a patent duct, the mean Doppler velocity in the main, right, and left pulmonary arteries were, respectively, 86 cm/sec +/- 5 standard error (SE), 120 +/- 7, and 125 +/- 8. With closed duct, the comparable velocities were 102 cm/sec +/- 7, 129 +/- 8, and 190 +/- 11. The only significant difference was the higher velocity in the left pulmonary artery associated with a closed duct (p = 0.00003). This physiologic origin of left-branch stenosis associated with ductal constriction should be considered when a murmur is detected after administration of indomethacin (in addition to possible persistent ductal flow), and as an explanation for some murmurs in the normal newborn. No anatomic or physiologic support was found for the theories that murmurs in the neonate were due to ductal flow, or to acute angulation of the branch pulmonary arteries.
W G Guntheroth
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  19     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1998 May-Jun
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-2     Citation Subset:  IM    
Department of Pediatrics (Cardiology), University of Washington School of Medicine, Seattle 98195-6320, USA.
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MeSH Terms
Blood Flow Velocity
Constriction, Pathologic
Ductus Arteriosus / physiology
Ductus Arteriosus, Patent / physiopathology*
Echocardiography, Doppler
Infant, Newborn
Infant, Premature
Pulmonary Artery / pathology,  physiology*,  ultrasonography
Retrospective Studies
Videotape Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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