Document Detail


The role of dietary fat in adipose tissue metabolism.
MedLine Citation:
PMID:  17903320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Energy intake and expenditure tend on average to remain adjusted to each other in order to maintain a stable body weight, which is only likely to be sustained if the fuel mix oxidised is equivalent to the nutrient content of the diet. Whereas protein and carbohydrate degradation and oxidation are closely adjusted to their intakes, fat balance regulation is less precise and that fat is more likely to be stored than oxidised. It has been demonstrated that dietary fatty acids have an influence not only on the fatty acid composition of membrane phospholipids, thus modulating several metabolic processes that take place in the adipocyte, but also on the composition and the quantity of different fatty acids in adipose tissue. Moreover, dietary fatty acids also modulate eicosanoid presence, which have hormone-like activities in lipid metabolism regulation in adipose tissue. Until recently, the adipocyte has been considered to be no more than a passive tissue for storage of excess energy. However, there is now compelling evidence that adipocytes have a role as endocrine secretory cells. Some of the adipokines produced by adipose tissue, such as leptin and adiponectin, act on adipose tissue in an autocrine/paracrine manner to regulate adipocyte metabolism. Furthermore, dietary fatty acids may influence the expression of adipokines. The nutrients are among the most influential of the environmental factors that determine the way adipose tissue genes are expressed by functioning as regulators of gene transcription. Therefore, not only dietary fat amount but also dietary fat composition influence adipose tissue metabolism.
Authors:
Alfredo Fernández-Quintela; Itziar Churruca; Maria Puy Portillo
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Public health nutrition     Volume:  10     ISSN:  1368-9800     ISO Abbreviation:  Public Health Nutr     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-02-01     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9808463     Medline TA:  Public Health Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1126-31     Citation Subset:  IM    
Affiliation:
Department of Nutrition and Food Science, University of País Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism,  physiology*
Adipokines / metabolism
Adipose Tissue / chemistry,  cytology,  metabolism,  physiology*
Dietary Fats / metabolism*,  pharmacology
Energy Metabolism / physiology*
Humans
Leptin / metabolism
Paracrine Communication
Chemical
Reg. No./Substance:
0/Adipokines; 0/Dietary Fats; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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