| The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases. | |
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MedLine Citation:
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PMID: 18667234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daidzein is a very good candidate for treating cardio-cerebrovascular diseases, but its poor oral absorption and bioavailability limit its curative efficacy. In this work, daidzein-loaded solid lipid nanoparticles (SLNs) with PEGylated phospholipid as stabilizer were successfully prepared by hot homogenization method. SLNs showed the mean particle size 126+/-14 nm with entrapment efficiency 82.5+/-3.7%. In vitro release of SLNs demonstrated a sustained release manner with cumulative release over 90% within 120 h in bovine serum albumin solution (4%, w/v). The pharmacokinetic behavior showed that SLNs loading daidzein could significantly increase circulation time compared with orally administrated daidzein suspension or intravenously delivered daidzein solution. SLNs showed the better effect on cardiovascular system of the anesthetic dogs by reducing the myocardial oxygen consumption (MOC) and the coronary resistance (CR) in heart compared with oral suspension or intravenous solution. The SLNs demonstrated the best effect on cerebrovascular system by increasing cerebral blood flow (CeBF) and reducing cerebrovascular resistance (CeR) in anesthetized dogs, and the protective effect on rats with ischemia-reperfusion injury model among three formulations. These results suggested that SLNs could be a potential candidate for the treatment of cardio-cerebrovascular diseases. |
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Authors:
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Yu Gao; Wangwen Gu; Lingli Chen; Zhenghong Xu; Yaping Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-29 |
Journal Detail:
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Title: Biomaterials Volume: 29 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 4129-36 Citation Subset: IM |
Affiliation:
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Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects* Brain Ischemia / diagnosis, drug therapy* Dogs Drug Carriers / administration & dosage*, chemistry* Isoflavones / administration & dosage*, chemistry Lipids / chemistry* Male Nanoparticles / chemistry* Phytoestrogens / administration & dosage, chemistry Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Isoflavones; 0/Lipids; 0/Phytoestrogens; 486-66-8/daidzein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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