Document Detail


The role of d-lactate in differential diagnosis of acute appendicitis.
MedLine Citation:
PMID:  20690847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Early diagnosis of acute appendicitis, known as the most frequent cause of acute surgical abdominal pathologies, dramatically decreases the related complications. D-lactate, produced by intestinal bacteria as a fermentation product, may be useful in diagnosing acute abdominal pathologies. The aim of this study was to investigate whether the presence of d-lactate would be a significant indicator in the early diagnosis of acute appendicitis.
METHODS: Eighty consecutive patients were prospectively included in this study. The patients were divided into four groups: acute appendicitis (group 1), perforated acute appendicitis (group 2), nonspecific abdominal pain (group 3), and acute abdomen other than acute appendicitis (group 4). For the control group, blood samples were taken in the same manner from 20 healthy subjects.
RESULTS: There was no significant difference in blood d-lactate levels between the simple acute appendicitis and acute perforated appendicitis groups (p > .05). The blood d-lactate levels in groups 1 and 2 were significantly higher than those in groups 3 and 4, and the control group (p < .001). The reliability of d-lactate was determined as 97% sensitivity, 93% specificity, 90% positive predictive and 95% negative predictive values, and 95% accuracy.
CONCLUSIONS: Based on findings in this study, blood d-lactate level may be a valuable diagnostic marker for the diagnosis of acute appendicitis.
Authors:
Ali Ilker Filiz; Hakan Aladag; Mehmet Levhi Akin; Ilker Sucullu; Yavuz Kurt; Ergun Yucel; Ahmet Haldun Uluutku
Related Documents :
19556737 - Intramedullary spinal cord abscess treated with antibiotic therapy--case report and rev...
2800877 - Systemic prophylaxis with doxycycline in intestinal surgery on patients with high incid...
25488057 - Prevention and treatment of postoperative crohn's disease recurrence with anti-tnf ther...
3535227 - Review of corynebacterium (rhodococcus) equi lung abscesses in foals: pathogenesis, dia...
15994747 - Limited predictive value of an acute test with subcutaneous octreotide for long-term ig...
20353467 - Vascular stents in the management of portal venous complications in living donor liver ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  23     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul 34668, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / blood,  diagnosis*
Acute Disease
Adolescent
Adult
Aged
Appendicitis / blood,  diagnosis*
Biological Markers / blood
Case-Control Studies
Diagnosis, Differential
Female
Humans
Lactic Acid / blood*
Male
Middle Aged
Prospective Studies
Sensitivity and Specificity
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quantification of ischemia-reperfusion injury to the small intestine using a macroscopic score.
Next Document:  The benefits of ligating the lobar portal triads before partial hepatectomy in the mouse.