Document Detail

The role of d-lactate in differential diagnosis of acute appendicitis.
MedLine Citation:
PMID:  20690847     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Early diagnosis of acute appendicitis, known as the most frequent cause of acute surgical abdominal pathologies, dramatically decreases the related complications. D-lactate, produced by intestinal bacteria as a fermentation product, may be useful in diagnosing acute abdominal pathologies. The aim of this study was to investigate whether the presence of d-lactate would be a significant indicator in the early diagnosis of acute appendicitis.
METHODS: Eighty consecutive patients were prospectively included in this study. The patients were divided into four groups: acute appendicitis (group 1), perforated acute appendicitis (group 2), nonspecific abdominal pain (group 3), and acute abdomen other than acute appendicitis (group 4). For the control group, blood samples were taken in the same manner from 20 healthy subjects.
RESULTS: There was no significant difference in blood d-lactate levels between the simple acute appendicitis and acute perforated appendicitis groups (p > .05). The blood d-lactate levels in groups 1 and 2 were significantly higher than those in groups 3 and 4, and the control group (p < .001). The reliability of d-lactate was determined as 97% sensitivity, 93% specificity, 90% positive predictive and 95% negative predictive values, and 95% accuracy.
CONCLUSIONS: Based on findings in this study, blood d-lactate level may be a valuable diagnostic marker for the diagnosis of acute appendicitis.
Ali Ilker Filiz; Hakan Aladag; Mehmet Levhi Akin; Ilker Sucullu; Yavuz Kurt; Ergun Yucel; Ahmet Haldun Uluutku
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  23     ISSN:  1521-0553     ISO Abbreviation:  J Invest Surg     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  218-23     Citation Subset:  IM    
Department of General Surgery, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Istanbul 34668, Turkey.
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MeSH Terms
Abdominal Pain / blood,  diagnosis*
Acute Disease
Appendicitis / blood,  diagnosis*
Biological Markers / blood
Case-Control Studies
Diagnosis, Differential
Lactic Acid / blood*
Middle Aged
Prospective Studies
Sensitivity and Specificity
Young Adult
Reg. No./Substance:
0/Biological Markers; 50-21-5/Lactic Acid

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